Etopiryna Extra (250 mg+200 mg+50 mg) x 10 tablets

Directions for use: use w/o doctor's instructions.
Refer to the package insert for detailed directions for use.

Storage: Store at ambient temperature

Acetylsalicylic Acid

Zakłady Farmaceutyczne Polpharma S.A.

Zakłady Farmaceutyczne Polpharma S.A.,
19 Pelplińska street,
83-200 Starogard Gdański,
POLAND

Taking the product at the lowest effective dose for the shortest period of time necessary to relieve symptoms reduces the risk of side effects. Acetylsalicylic acid may trigger an asthma attack in hypersensitive patients. Very rarely, cases of severe skin reactions, which can be fatal like Stevens-Johnson syndrome, have been reported after taking non-steroidal anti-inflammatory drugs (NSAIDs). Taking the product should be discontinued at the first appearance of skin lesions like rash, mucosal lesions or any other symptoms of hypersensitivity. Patients with inflammatory bowel disease, blood clotting disorders, asthma or a history of allergic disease should consult a doctor before starting treatment. Elderly patients. The incidence of NSAID-specific side effects increases with age, especially intestinal bleeding and intestinal perforation, which can be fatal. The product should not be used in patients taking oral antidiabetic drugs of the sulfonylurea derivative group, due to the risk of increased hypoglycemic effects, and in patients taking gout medications. Because acetylsalicylic acid and its metabolites are excreted in the urine there is a greater risk of adverse effects in patients with renal impairment and chronic renal failure. In patients with juvenile rheumatoid arthritis, systemic lupus erythematosus, with concomitant liver damage, salicylate toxicity is increased - liver function tests should be performed in these patients. Use the product with caution in patients with a history of hypoprothrombinemia, vitamin K deficiency, thrombocytopenia, severe renal impairment and those treated with anticoagulant products. Acetylsalicylic acid should be discontinued 5-7 days before planned surgery, due to decreased blood clotting and increased risk of bleeding. Caution should be exercised when used with methotrexate at doses of less than 15 mg per week, due to an increase in the toxic effect of methotrexate on the bone marrow. Concomitant use with methotrexate in doses greater than 15 mg per week is contraindicated. Use with caution in cases of: uterine hemorrhages, excessive menstrual bleeding, IUD use, gout, gout, urate diathesis, hypertension, and heart failure in patients with intracranial bleeding. Alcohol should not be consumed during treatment with acetylsalicylic acid, as there is a greater risk of gastrointestinal side effects and an increased risk of liver damage. Particularly the risk of liver damage exists in patients who are starving and regularly consume alcohol. In elderly patients, use lower doses and increase the interval between doses of acetylsalicylic acid. These patients are more likely to experience gastric mucosal irritation and gastrointestinal bleeding. The pharmacokinetics of acetylsalicylic acid may also change. There is evidence that drugs that inhibit cyclooxygenase (prostaglandin synthesis) can cause fertility disorders in women by affecting ovulation. This effect is transient and disappears after treatment is discontinued. Due to the risk of overdose, the drug product should not be used concomitantly with other drugs containing paracetamol and/or acetylsalicylic acid and/or caffeine. Avoid concomitant use of Etopyrin Extra with NSAIDs including cyclooxygenase inhibitors. Caution should be exercised in patients with hypertension and/or heart failure, as fluid retention and edema have been observed in association with NSAID use. The product should be used with caution in patients with psychomotor agitation. Simultaneous long-term use of paracetamol and acetylsalicylic acid in high doses increases the risk of analgesic nephropathy. Effects on laboratory test results. The use of paracetamol may cause unreliable results in tests determining uric acid concentration (phosphoric acid method) and blood sugar concentration (oxidase-peroxidase method). Caution should be exercised during concomitant use of paracetamol and flucloxacillin, due to the increased risk of developing high anion gap metabolic acidosis (HAGMA), especially in patients with severe renal impairment, sepsis, malnutrition and other causes of glutathione deficiency (e.g. chronic alcoholism), as well as in patients using maximum daily doses of paracetamol. Close observation of the patient, including urine 5-oxoproline detection tests, is recommended. The product contains hydrogenated castor oil, which may cause indigestion and diarrhea.